Description

LABEL ESMOLOL is a specialized intravenous medication designed for acute care settings, offering rapid and precise control over heart rate and blood pressure. As a beta-1 selective adrenergic blocker, it is particularly effective in managing perioperative and postoperative tachyarrhythmias and hypertension, providing healthcare professionals with a reliable tool for short-term cardiovascular intervention.

Indications

This medication is primarily indicated for:

• Atrial fibrillation
• Atrial flutter
• Noncompensatory sinus tachycardia

Its use is intended for situations requiring immediate and short-term management, with treatment durations not exceeding 24 hours.

Administration

Available in various intravenous formulations, LABEL ESMOLOL allows for flexible dosing through bolus and infusion regimens. Its rapid onset within 60 seconds and a short half-life of approximately 9 minutes enable quick adjustments to therapeutic needs. The medication is metabolized by erythrocyte esterases, ensuring minimal renal or hepatic impact, thus requiring no dose adjustments for patients with related impairments.

Packaging

The product is supplied in clear, sterile, nonpyrogenic solutions, available in single-dose vials and premixed infusion bags. It is preservative-free and intended for single use only, with packaging options that include:

• 10 mL vials
• 100 mL bags
• 250 mL bags

Storage

Storage conditions require a controlled room temperature between 20–25°C, with protection from freezing and excessive heat. Each dose should be inspected for particulate matter or discoloration prior to use.

Contraindications

Contraindications for LABEL ESMOLOL include:

• Sinus bradycardia
• Heart block greater than first degree
• Cardiogenic shock
• Overt heart failure

Precautions

Caution is advised for patients with bronchospastic diseases, diabetes, or impaired renal function. Continuous monitoring of blood pressure, heart rate, and ECG is essential during administration, with an arterial line preferred for accurate blood pressure measurement.

Adverse Effects

Common adverse effects may include hypotension, bradycardia, and infusion site reactions, while serious effects are rare but can involve significant cardiovascular responses. In case of overdose, discontinuation and supportive care are recommended.

Drug Interactions

Notable drug interactions include those with digoxin, calcium channel blockers, and catecholamine-depleting drugs, necessitating careful management during concurrent use.

Compliance

Manufactured in compliance with regulatory standards, LABEL ESMOLOL is a prescription-only medication, free from latex and allergens, and compliant with the Trade Agreements Act. It serves as a generic equivalent to Brevibloc Injection, with no requirements for Risk Evaluation and Mitigation Strategies (REMS).

This comprehensive profile underscores LABEL ESMOLOL's role as a critical therapeutic agent in acute cardiovascular care, offering precision, reliability, and safety for healthcare providers managing complex cardiac conditions.