Description

METABOLICS MR TAB is a specialized modified release tablet designed for the management of various medical conditions, depending on its active ingredient. As a prescription-only medicine, it is classified under Schedule 4 or Schedule 8 in Australia, ensuring its use is carefully monitored by healthcare professionals.

Active Ingredients and Indications

Desvenlafaxine (as Benzoate)

• Indication: Primarily used for the treatment of depression and related disorders.
• Strengths: Available in 50 mg and 100 mg extended release forms.
• Dosage: Typically administered once daily, with adjustments for individuals with kidney issues.

Isosorbide Mononitrate

• Indication: Used for the prophylactic treatment of angina pectoris.
• Strength: Available in a 60 mg modified release form.
• Dosage: Generally taken once daily, with the option to increase the dose if necessary.

Morphine Sulfate Pentahydrate

• Indication: Provides pain management as an analgesic.
• Strengths: Available in 10 mg, 30 mg, 60 mg, and 100 mg modified release forms.

Administration Instructions

• Method: Tablets should be swallowed whole with water and not divided, crushed, or chewed.
• Consistency: Recommended to be taken at the same time each day for optimal effectiveness.

Pharmacological Considerations

• Desvenlafaxine: Not a substrate or inhibitor for several cytochrome P450 enzymes, but may affect drugs metabolized by CYP2D6. It crosses the placenta and is excreted in human milk, necessitating caution during pregnancy and lactation.
• Isosorbide Mononitrate: Features a hydrophobic cellulose matrix for gradual release, with a half-life of approximately 5 hours.

Side Effects and Interactions

• Common Side Effects: May include nausea, dizziness, headache, and sleep disturbances.
• Serious Side Effects: Can involve muscle spasms, hallucinations, or increased bleeding.
• Drug Interactions: Caution advised with MAOIs, other antidepressants, and alcohol.

Excipients and Physical Description

• Desvenlafaxine Excipients: Includes microcrystalline cellulose, hypromellose, and Opadry II film coating.
• Isosorbide Mononitrate Excipients: Contains lactose monohydrate, hypromellose, and titanium dioxide.
• Morphine Sulfate Excipients: Features lactose monohydrate and various Opadry coatings based on strength.

Packaging and Storage

• Packaging: Tablets are packaged in blister packs with varying sizes.
• Storage: Should be stored below 25°C in a dry place, protected from light and moisture.
• Disposal: Unused medicine should be returned to a pharmacy for safe disposal.

Important Considerations

• Use During Pregnancy: Should only be used if the benefits outweigh the risks.
• Lactose Content: Relevant for those with lactose intolerance, particularly with Isosorbide Mononitrate and Morphine Sulfate variants.

This comprehensive formulation ensures that METABOLICS MR TAB meets the therapeutic needs of patients while maintaining safety and efficacy through its controlled release mechanism. Always consult a healthcare provider for personalized medical advice and confirmation of the appropriate variant and strength for individual needs.